MUMBAI, India, May 29 -- Intellectual Property India has published a patent application (202641041655 A) filed by Srm Dental College, Chennai, Tamil Nadu, on April 1, for 'polydopamine coated liposomes as ph sensitive carriers of proanthocyanidin for resindentin bonding.'
Inventor(s) include Dr. S. Vidhya; Dr. A. R. Lakshmi Nivashini; Dr. A. Keerthivasan; and Dr. S. Mahalaxmi.
The application for the patent was published on May 29, under issue no. 22/2026.
According to the abstract released by the Intellectual Property India: "The present innovation relates to a dentin pretreatment agent comprising of proanthocyanidin (PAC) encapsulated within poly dopamine (PDA)-coated liposomes (LPMs). This targeted delivery system is based on a core-shell design, wherein the PAC solution forms the core and the PDA-coated LPM acts as the shell. The system is intended to biomodify dentin by releasing PAC in the acidic environment of the resin-dentin (R- D) interface, thereby enhancing the long-term bond strength of composite resin restorations. Degradation of the R-D bond is primarily associated with collagen fibril breakdown within the hybrid layer. PAC, derived from grape seeds, is known to inhibit matrix metalloproteinases and induce collagen cross-linking at the interface. PDA-coated LPMs enable pH-sensitive delivery of PAC into demineralized dentinal collagen while protecting the drug from degradation and ensuring biocompatibility. The PDA coating further stabilizes LPMs and enhances adhesion. Collectively, protease inhibition, collagen stabilization, adhesion promotion, and biocompatibility make this system a promising dentin pretreatment strategy for improving restoration durability."
Disclaimer: Curated by HT Syndication.
