MUMBAI, India, Jan. 2 -- Intellectual Property India has published a patent application (202541122154 A) filed by Vellore Institute Of Technology, Vellore, Tamil Nadu, on Dec. 4, 2025, for 'plant-derived exosomes for anti-inflammatory therapy.'
Inventor(s) include Dr Ramasamy Tamizhselvi; Ms. Aishy Chakraborty; Aparna Eledath Kolasseri; and Dr Sivaraman Jayanthi.
The application for the patent was published on Jan. 2, under issue no. 01/2026.
According to the abstract released by the Intellectual Property India: "The present disclosure provides an anti-inflammatory composition comprising plant derived exosomes isolated from Annona squamosa leaves, wherein the exosomes have a size range of 30-150 nm and contain bioactive compounds, and wherein the exosomes exhibit anti-inflammatory activity through modulation of steroid hormone biosynthesis pathways. The bioactive compounds comprise oxepane having a binding affinity of 5.1 kcal/mol to CYP11A1 protein. The disclosure further provides a method of producing anti-inflammatory plant-derived exosomes comprising obtaining fresh Annona squamosa leaves, blending with phosphate buffered saline, performing sequential centrifugation to remove debris, ultracentrifuging the filtered supernatant at 150,000 g for 90 minutes at 4 C to obtain a pellet, and resuspending in phosphate buffered saline. The disclosure also provides a pharmaceutical formulation comprising the anti-inflammatory composition and a pharmaceutically acceptable carrier."
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