MUMBAI, India, Feb. 13 -- Intellectual Property India has published a patent application (202541125783 A) filed by Harini P; Nancy A; and Dr. S. Hari Lakshmi, Coimbatore, Tamil Nadu, on Dec. 12, 2025, for 'piper cubeba seed based herbal nasal spray: a novel antimicrobial and anti-inflammatory formulation for respiration health.'
Inventor(s) include Harini P; Nancy A; and Dr. S. Hari Lakshmi.
The application for the patent was published on Feb. 13, under issue no. 07/2026.
According to the abstract released by the Intellectual Property India: "The present invention relates to a novel herbal nasal spray formulation compnsmg a standardized extract of Piper cubeba L. seeds, developed for the localized management of respiratory tract infections and inflammation. The active extract is obtained through green extraction methods, preferably supercritical fluid extraction or ethanol maceration, and is standardized for its key bioactive lignan, cubebin. The extract is formulated into a stable, isotonic aqueous solution using pharmaceutically acceptable excipients, including mucoadhesive agents, humectants, and preservatives, with the pH and osmolality adjusted to match nasal physiological conditions. The resultant formulation is filled aseptically into a metered-dose nasal spray delivery system. The invention provides a dual-action therapeutic, demonstrating significant in vitro antimicrobial efficacy against key respiratory pathogens-including Staphylococcus aureus and Streptococcus pneumoniae -and anti-inflammatory activity by inhibiting nitric oxide and proinflammatory cytokines. The nasal spray exhibits favorable physicochemical properties, including appropriate viscosity, droplet size distribution, and spray pattern, and maintains stability under accelerated storage conditions. This invention offers a natural, patient-friendly, and non-invasive alternative to conventional respiratory therapeutics by harnessing the synergistic bioactivity of a traditional medicinal plant in a modern dosage form. It is intended for use in the preyention and symptomatic relief of conditions such as sinusitis, bronchitis, and allergic rhinitis, presenting a scalable and scientifically validated approach to phytopharmaceutical innovation."
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