MUMBAI, India, Feb. 13 -- Intellectual Property India has published a patent application (202521133872 A) filed by Rishit Atulbhai Soni; Janki Manojkumar Trivedi; Ashish Tribhuvan Bhatt; Dr. Nidhi Bankim Soni; Dr. Jayeshkumar Rameshchandra Ruparelia; and Priyanka Gajjar, Anand, Gujarat, on Dec. 30, 2025, for 'phage cage: a nano particulate trojan horse for combating resistant hospital infections.'
Inventor(s) include Rishit Atulbhai Soni; Janki Manojkumar Trivedi; Ashish Tribhuvan Bhatt; Dr. Nidhi Bankim Soni; Dr. Jayeshkumar Rameshchandra Ruparelia; and Priyanka Gajjar.
The application for the patent was published on Feb. 13, under issue no. 07/2026.
According to the abstract released by the Intellectual Property India: "Disclosed herein is "Phage Cage, a lipid nanoparticle (LNP)-based delivery composition for the treatment of infections caused by multidrug-resistant (MDR) pathogens". The composition comprises bacteriophages encapsulated within lipid nanoparticles. The nanoparticles include one or more ionizable lipids, helper phospholipids, cholesterol, and polyethylene glycol (PEG)- lipid conjugates, forming a protective matrix that stabilizes the phage payload during storage and systemic circulation. In certain embodiments, the lipid nanoparticles are surface- functionalized with pathogen-targeting ligands, including but not limited to antibodies, peptides, or carbohydrate-binding moieties, to enhance selective accumulation at the infection site. In other embodiments, the nanoparticles may incorporate pH-sensitive or enzyme- cleavable lipids to facilitate controlled release of the phage payload under infection-specific micro environmental conditions. The system may further comprise biofilm-disrupting agents co-encapsulated or co-delivered with the phages to enhance penetration into resistant microbial communities. The disclosed compositions and methods provide a scalable Nano platform for targeted delivery of phages against MDR pathogens in nosocomial and community-acquired infections, suitable for inhalation-based administration."
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