MUMBAI, India, Nov. 21 -- Intellectual Property India has published a patent application (202521104713 A) filed by Ms. Shraddha Dhananjay Patil; and Mrs. Swati B. Udugade, Karad, Maharashtra, on Oct. 30, for 'ph-sensitive liposomes for the targeted delivery of an antifungal agent in fungal infection.'
Inventor(s) include Ms. Shraddha Dhananjay Patil; Mrs. Swati B. Udugade; Mr. Mahesh Prakash Patil; Mr. Vikrant Anil Patil; Ms. Neha Ashok Pawar; and Ms. Jyotsna Jaysing Patil.
The application for the patent was published on Nov. 21, under issue no. 47/2025.
According to the abstract released by the Intellectual Property India: "The present invention relates to pH-sensitive liposomal formulations for targeted delivery of antifungal agents, particularly Itraconazole, in the treatment of fungal infections. The liposomes comprise phospholipids and cholesterol in a defined molar ratio with a pH-responsive N-isopropyl acrylamide (NIPAAm)-based copolymer incorporated into the bilayer. The system exhibits controlled, site-specific drug release-less than 15% at physiological pH 7.4 and more than 60% at acidic pH 5.5, characteristic of infected tissues. The nanosized unilamellar vesicles (65-120 nm) demonstrate high entrapment efficiency (above 90%), negative zeta potential, and enhanced drug solubility and stability. The optimized formulation exhibits superior antifungal efficacy against Candida albicans compared to pure Itraconazole, with reduced systemic toxicity. The invention provides an efficient, biocompatible, and stable liposomal platform for pH-triggered antifungal drug delivery."
Disclaimer: Curated by HT Syndication.
