MUMBAI, India, Jan. 2 -- Intellectual Property India has published a patent application (202541123170 A) filed by M. Thanga Kokila, Krishnankoil, Tamil Nadu, on Dec. 6, 2025, for 'patent for formulation and evaluation of hollow microsphere drug delivery system of acyclovir.'
Inventor(s) include Dr. N. Venkateshan; P. Sriganeshan; B. Dharani Priya; P. Kowsalya; Chrisil Auxi. N; Abinaya. M; Mallika. A; Kowsalya. M; and Roshan. C.
The application for the patent was published on Jan. 2, under issue no. 01/2026.
According to the abstract released by the Intellectual Property India: "The study focused on developing floating hollow microspheres of Acyclovir to improve oral bioavailability and provide sustained release. Microspheres were prepared using the emulsion solvent diffusion method with Eudragit RS100 and RL100 polymers. Among seven formulations (F1-F7), Formulation F4 (Acyclovir:Eudragit RL100 = 1:2) was optimised, showing high yield (90.45%), excellent entrapment efficiency (94.40%), strong buoyancy (90% for 10 hours), and sustained drug release for up to 12 hours.FTIR and DSC confirmed drug-polymer compatibility, while SEM images showed spherical porous microspheres supporting buoyancy and controlled release. Drug release followed zero-order kinetics with a non-Fickian mechanism. In-vivo X-ray studies confirmed gastric retention for 8 hours, and stability studies showed no significant changes. Overall, the optimised F4 formulation provides an effective gastroretentive system that enhances Acyclovir bioavailability through prolonged gastric residence and sustained release."
Disclaimer: Curated by HT Syndication.
