MUMBAI, India, May 1 -- Intellectual Property India has published a patent application (202621028961 A) filed by Lnct University, Bhopal, Madhya Pradesh, on March 11, for 'optimized nanostructured lipid carrier system for enhanced bioavailability of naringenin using box-behnken design.'
Inventor(s) include Tanveer Khan; and Dr. Ashish Jain.
The application for the patent was published on May 1, under issue no. 18/2026.
According to the abstract released by the Intellectual Property India: "The present invention relates to an optimized nanostructured lipid carrier (NLC) system for improving the solubility and bioavailability of naringenin, a bioactive flavanone with significant therapeutic potential but limited aqueous solubility and low oral bioavailability. The formulation comprises a combination of solid lipid, liquid lipid, and surfactant components, wherein stearic acid functions as the solid lipid, oleic acid as the liquid lipid, and polyethylene glycol 600 (PEG 600) as the surfactant. The formulation parameters were optimized using Box-Behnken response surface methodology to evaluate the effects of oleic acid, PEG 600, and stearic acid concentrations on nanoparticle particle size and entrapment efficiency. The optimized formulation containing approximately 6 mg oleic acid, 11% PEG 600, and 75 mg stearic acid produced nanoparticles with particle size of approximately 150 nm and entrapment efficiency of about 88-90%, thereby enhancing the stability and therapeutic potential of naringenin."
Disclaimer: Curated by HT Syndication.
