MUMBAI, India, Feb. 6 -- Intellectual Property India has published a patent application (202541123603 A) filed by Saveetha Institute Of Medical And Technical Sciences, Chennai, Tamil Nadu, on Dec. 8, 2025, for 'novel topical nail lacquer formulation containing 0.1% tretinoin and 6% salicylic acid for the management of nail hickening disorders secondary to inflammatory conditions.'
Inventor(s) include G. G. Hari Shankar; Vinay Kumar; and Deepak Nallaswamy Veeraiyan.
The application for the patent was published on Feb. 6, under issue no. 06/2026.
According to the abstract released by the Intellectual Property India: "Nail thickening disorders secondary to inflammatory conditions such as psoriasis, lichen planus are challenging to manage due to limited efficacy and poor penetration of conventional topical agents. Systemic therapies can be etTective but carry risks of adverse effects and are unsuitable for long-term use in many patients. This study presents a novel fixed-dose topical nail lacquer containing Tretinoin 0.1% and Salicylic Acid 6%, engineered to target complementmy mechanisms in the management of inflammatory nail thickening. Tretinoin, a retinoid, drives keratinocyte turnover and decreases hyperkeratosis, addressing the underlying inflammatory and structural changes within the nail plate. Salicylic acid acts as a potent keratolytic, softening and thinning the thickened nail, thereby enhancing tretinoin penetration and direct keratin remodeling. The strategic combination of tretinoin and salicylic acid in a lacquer vehicle enables sustained nail contact, maximizes local efficacy, and reduces systemic absorption and associated risks. This integrated approach offers a promising, user-friendly alternative for patients with nail thickening disorders, supporting improved nail function, appearance, and quality of life while minimizing adverse effects and complexity compared to systemic or multi-step topical reg1mens."
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