MUMBAI, India, Nov. 7 -- Intellectual Property India has published a patent application (202421035285 A) filed by LNCT University, Bhopal, Madhya Pradesh, on May 3, 2024, for 'novel rp-hplc method for estimation of donepezil hydrochloride: development and validation.'
Inventor(s) include Sunayana Kesharwani; Shubham Gautam; and Parul Mehta.
The application for the patent was published on Nov. 7, under issue no. 45/2025.
According to the abstract released by the Intellectual Property India: "This invention presents a modest and cost-effective stability-indicating method for quantitatively determining Donepezil Hydrochloride (DPH) using Reverse-Phase High-Performance Liquid Chromatography (RP-HPLC). Employing a Thermo C18 column (250mm x 4.60mm, 5 particle size) bonded with Octadecylsilane (C18), the method utilizes a mobile phase consisting of 50% Methanol and 50% Acetonitrile for efficient separation. Analysis is conducted at ambient temperature with a flow rate of 1.0 ml/min, and a 20 l sample is injected into the system, with detection occurring at a wavelength of 268nm. The retention time for Donepezil Hydrochloride is determined to be 5.680 0.01 minutes. This method offers a dependable and sensitive approach for determining Donepezil Hydrochloride, rendering it suitable for stability-indicating assays in pharmaceutical formulations."
Disclaimer: Curated by HT Syndication.
