MUMBAI, India, Oct. 11 -- Intellectual Property India has published a patent application (202441028148 A) filed by Neuland Laboratories Limited, Hyderabad, Telangana, on April 5, 2024, for 'novel process for the preparation of difelikefalin acetate.'
Inventor(s) include Dr. Sharadsrikar Venkatesan Kotturi; Dr. Gandavadi Sunil Kumar; and Mr. Parumanchala Shaik Shavali.
The application for the patent was published on Oct. 10, under issue no. 41/2025.
According to the abstract released by the Intellectual Property India: "Novel process for the preparation of Difelikefalin Acetate having the structural Formula I. which comprises: activation of N-protected-D-Phe-OH in presence of activating agent followed by coupling with H-D-Phe-OH to obtain N-protected-D-Phe-D-Phe-OH dipeptide which is sequential activation and coupling with H-D-Leu-OH, H-D-Lys(P)-OH and P-Pip-OH to obtain protected Difelikefalin then global deprotection in presence of acid and solvent to obtain Difelikefalin HCl. Purification of Difelikefalin HCl in presence of ammonium acetate, purified water and acetonitrile and followed by salt exchange with acetic acid to obtain Difelikefalin Acetate."
Disclaimer: Curated by HT Syndication.
