MUMBAI, India, Nov. 21 -- Intellectual Property India has published a patent application (202511093866 A) filed by Amar Shaheed Baba Ajit Singh Jujhar Singh Memorial College Of Pharmacy, Ropar, Punjab, on Sept. 30, for 'nanosponge tablets for controlled release of ramipril and related methods.'
Inventor(s) include Dr. Shailesh Sharma; Dr. Neelam Sharma; Jashanpreet Kaur; Shruti; Dr. Kumar Guarve; Dr. Anshu Sharma; and Dr. Praveen Kumar.
The application for the patent was published on Nov. 21, under issue no. 47/2025.
According to the abstract released by the Intellectual Property India: "The invention relates to a sustained-release oral tablet formulation containing Ramipril-loaded nanosponges. These nanosponges are prepared using an emulsion solvent diffusion method with ethyl cellulose and polyvinyl alcohol. The formulation includes hydroxypropyl methylcellulose as a release-retarding polymer, microcrystalline cellulose as a filler, colloidal silicon dioxide as a glidant, and magnesium stearate as a lubricant. It achieves a cumulative drug release of approximately 75% over 8 hours in a phosphate buffer, with release kinetics fitting the Korsmeyer-Peppas model. The formulation enhances the stability and bioavailability of Ramipril, with the nanosponges exhibiting particle sizes between 200 nm and 500 nm and an entrapment efficiency of at least 85%. The tablet demonstrates specific hardness, friability, and drug content uniformity, and maintains a stable release profile under accelerated stability conditions."
Disclaimer: Curated by HT Syndication.
