MUMBAI, India, Feb. 27 -- Intellectual Property India has published a patent application (202641017862 A) filed by Vel Tech Rangarajan Dr. Sagunthala R&D Institute Of Science And Technology, Chennai, Tamil Nadu, on Feb. 17, for 'mucoadhesive chitosan nanoparticle-based electrolyte-balanced artificial saliva composition.'
Inventor(s) include Dr. Shobana Sampath; Dr. C. V. Divyambika; Dr. K Jagajjanani Rao; and Yuvarani Krishnan.
The application for the patent was published on Feb. 27, under issue no. 09/2026.
According to the abstract released by the Intellectual Property India: "The present invention relates to a mucoadhesive chitosan nanoparticle-based artificial saliva composition for management of xerostomia. The formulation comprises stabilized chitosan nanoparticles integrated with physiologically balanced electrolyte ions including calcium, magnesium, sodium, potassium, and phosphate ions, along with sorbitol as humectant and sodium carboxymethyl cellulose as viscosity modifier. The nanoparticle system is formed through controlled ionic interaction between protonated chitosan and electrolyte ions to produce a monomodal dispersion exhibiting particle size in the range of 400-600 nm, low polydispersity index, and high zeta potential for electrostatic stabilization. The composition demonstrates enhanced mucosal retention, sustained lubrication, antimicrobial activity against oral pathogens, and high cytocompatibility with human gingival fibroblast cells. The invention provides a structurally stabilized, physiologically balanced artificial saliva suitable for pharmaceutical and oral healthcare applications."
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