MUMBAI, India, Feb. 6 -- Intellectual Property India has published a patent application (202541123419 A) filed by Saveetha Institute Of Medical And Technical Sciences, Chennai, Tamil Nadu, on Dec. 8, 2025, for 'mouthwash preparation using glorious superba mediated silver nanoparticles and thiocolchicoside.'
Inventor(s) include Rajeshkumar Shanmugam; Renu Vajjiravelu; Santhoshkumar Jayakodi; and Deepak Nallaswamy Veeraiyan.
The application for the patent was published on Feb. 6, under issue no. 06/2026.
According to the abstract released by the Intellectual Property India: "The present invention relates to a novel herbal-based antimicrobial mouthwash formulation incorporating Gloriosa superba-mediated silver nanoparticles (AgNPs) and Thiocolchicoside for effective oral hygiene management. The invention utilizes the aqueous or ethano lie extract of G. superba tubers or leaves as a bio-reductant and stabilizing agent for the eco-friendly, green synthesis of AgNPs. The biosynthesized AgNPs exhibit potent antimicrobial, antifungal, and anti-biofilm activities against a wide spectmm of oral pathogens, including S. aureus. S. mutans, C. albicans, and E. faecalis by using the agar well diffusion method. The plant extract's phytoconstituents, such as colchicine, gloriosine, and various flavonoids, enhance nanoparticle stability and synergize with silver's antimicrobial action. The mouthwash formulation is alcoholfree, non-irritating, and suitable for daily use. It provides rapid plaque inhibition, reduces gingival inflammation, neutralizes oral malodor, and aids in the prevention of dental caries and periodontitis. The invention addresses limitations of conventional mouthwashes, such as high alcohol content, synthetic chemical exposure, and resistance development. The method of preparation includes the extraction of Glorious superba, synthesis and characterization of AgNPs via UV-Vis, FTIR, XRD, and TEM, followed by incorporation into an optimized aqueous base with flavoring agents, pH stabilizers, and humectants. The resulting product shows enhanced shelf stability and sustained antimicrobial release. Cytotoxicity assays confirm biocompatibility with oral epithelial cells at effective concentrations. The invention provides a sustainable, costeffective, and multifunctional oral care solution derived from natural resources, promoting both oral and systemic health while minimizing environmental impact from chemical manufacturing."
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