MUMBAI, India, Feb. 6 -- Intellectual Property India has published a patent application (202541123425 A) filed by Saveetha Institute Of Medical And Technical Sciences, Chennai, Tamil Nadu, on Dec. 8, 2025, for 'moringa oleifera flower-infused chitosan based dental varnish for oral care.'
Inventor(s) include Dhanyaa Muthukumaran; Rajeshkumar Shanmugam; and Deepak Nallaswamy Veeraiyan.
The application for the patent was published on Feb. 6, under issue no. 06/2026.
According to the abstract released by the Intellectual Property India: "This research aims to evaluate the antimicrobial efficacy of M. oleifera flower-mediated chitosan dental varnish, highlighting its potential as an innovative approach in oral healthcare management. The antimicrobial efficacy of M. oleifera-loaded chitosan nanoparticles was assessed using agar well diffusion, MIC, and time-kill assays. The nanoparticles exhibited concentrationdependent inhibition against various pathogens, including Lactobacillus sp., Streptococcus mutans, Staphylococcus aureus, Enterococcus .faecalis, and Candida albicans. MIC testing against E. faecalis confirmed their bacteriostatic potential at low concentrations. Time-kill kinetic analysis further demonstrated concentration- and time-dependent bactericidal activity, highlighting their potential as effective alternative antimicrobial agents. MIC results showed a concentration-dependent reduction in optical density across all tested oral pathogens, with the strongest inhibition observed at the highest concentration, particularly against E. .faecalis and S. aureus. Time-kill analysis further confirmed a significant, dose- and time-dependent decline in microbial vi-ability, after 4 hours at the highest concentration. These findings highlight the potent and rapid antimicrobial activity of the nanoparticle-based varnish, underscoring its promise in managing oral pathogens and improving dental health. Chitosan nanoparticles have significantly advanced dental care by enhancing antimicrobial activity, drug delivery, and tissue regeneration. Incorporating bioactive agents, such as Moringa oleifera, further enhances therapeutic efficacy and biocompatibility. This synergy offers a promising, natural approach for preventing and managing oral diseases."
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