MUMBAI, India, March 13 -- Intellectual Property India has published a patent application (202641025520 A) filed by Vignan Institute Of Pharmaceutical Technology, Visakhapatnam, Andhra Pradesh, on March 4, for 'molecular docking studies of lichen metabolites as potential inhibitors of viral entry proteins.'
Inventor(s) include S. Kiranmai; R. Mohini; D. Rama Devi; G. Vasantha; and M. Naga Bharathi.
The application for the patent was published on March 13, under issue no. 11/2026.
According to the abstract released by the Intellectual Property India: "This invention proposes a computational method for identifying novel antiviral compounds. The system leverages advanced molecular docking simulations to evaluate the binding affinity and interaction mechanisms of various lichen metabolites against critical viral entry proteins. Viral entry proteins, such as glycoproteins or adhesion molecules, are essential for the virus to attach to and fuse with host cells, making them prime targets for therapeutic intervention. The proposed method begins by constructing high-resolution 3D models of target viral entry proteins and a diverse library of lichen metabolites. These metabolites, known for their rich chemical diversity and biological activities, are then computationally docked into the active sites or critical binding regions of the viral proteins. The docking procedure generates predicted binding poses and scores, indicating the potential inhibitory strength of each metabolite. Further analysis involves assessing hydrogen bonding, hydrophobic interactions, and van der Waals forces to elucidate the molecular basis of ligand-protein recognition. This approach offers a rapid, cost-effective, and ethical alternative to traditional experimental screening, enabling the early identification of promising lead compounds that can subsequently be validated through in vitro and in vivo studies. The ultimate goal is to accelerate the discovery and development of new antiviral drugs against a broad spectrum of viral pathogens."
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