MUMBAI, India, April 17 -- Intellectual Property India has published a patent application (202621022794 A) filed by Indian Institute Of Technology, Maharashtra, on Feb. 26, for 'mitochondrial g-quadruplex dna imaging probes based on benzoxadiazole scaffold.'
Inventor(s) include Pradeepkumar, P. I.; Dilnawaj, Y; and Waychal, Kedar Praveenkumar.
The application for the patent was published on April 17, under issue no. 16/2026.
According to the abstract released by the Intellectual Property India: "The present invention provides an organic probe compound of formula I targeting specific Mitochondrial G-quadruplexes (mtG4 DNAs), and a method for synthesis thereof. The invention provides synthesis of specific benzoxadiazole probe compound of formula II BnQ and formula III BnI for the detection of mtG4 DNAs in live cell systems. The probes are attached with TPP group, which helps the probe enter mitochondria, and the dye part of the probe interacts with mtG4 DNAs. Probes have displayed the selective fluorescence light-up properties with various mtG4 DNAs. Probe of Formula II exhibited a bright red fluorescence signal in live HeLa cells corresponding to thread-like mitochondrial structures. This fluorescence arises from the interaction of the probe with mt G4 DNAs."
Disclaimer: Curated by HT Syndication.
