MUMBAI, India, May 29 -- Intellectual Property India has published a patent application (202621042286 A) filed by Dr. Ritesh Amol Fule; Ms. Kaveri Ruprao Nighot; and Mr. Pankaj Dnyaneshwar Nagpure, Nagpur, Maharashtra, on April 2, for 'microneedle patch with tioconazole-loaded plga microparticles for sustained transdermal delivery in fungal infections.'
Inventor(s) include Dr. Ritesh Amol Fule; Ms. Kaveri Ruprao Nighot; Mr. Pankaj Dnyaneshwar Nagpure; Mr. Krunal Uttam Bisandre; Dr. Mangesh Dinanath Godbole; Dr. Rohit Ashokkumar Gupta; and Ms. Neha Vijay Patil.
The application for the patent was published on May 29, under issue no. 22/2026.
According to the abstract released by the Intellectual Property India: "The invention relates to a transdermal microneedle patch (100) for delivery of an antifungal agent. The patch (100) comprises a microneedle array (102) formed from a biodegradable polymeric matrix configured to penetrate the stratum corneum of skin, and a plurality of polymeric microparticles (104) embedded within the microneedles, the microparticles (104) comprising tioconazole encapsulated in a poly (D, L-lactide-co-glycolide) (PLGA) polymer matrix. Upon insertion of the microneedle array (102) into the skin, the microneedles dissolve or swell to release the microparticles (104) into epidermal or dermal layers, thereby enabling controlled and sustained transdermal delivery of tioconazole. The invention further relates to a method (200) for preparing the polymeric microparticles (104), comprising dissolving (202) tioconazole and PLGA in an organic solvent, dispersing (204) the organic phase into an aqueous phase containing polyvinyl alcohol to form an emulsion, subjecting (206) the emulsion to sonication, and evaporating (208) the solvent to obtain tioconazole-loaded PLGA microparticles."
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