MUMBAI, India, May 29 -- Intellectual Property India has published a patent application (202621049540 A) filed by Rushikesh Ambadas Kantale; Shivani Ambadas Kantale; and Kirti Rushikesh Kantale, Amravati, Maharashtra, on April 18, for 'microenvironment-responsive self-assembling in-situ drug depot system for periodontal therapy.'
Inventor(s) include Rushikesh Ambadas Kantale; Shivani Ambadas Kantale; and Kirti Rushikesh Kantale.
The application for the patent was published on May 29, under issue no. 22/2026.
According to the abstract released by the Intellectual Property India: "The present invention relates to a microenvironment-responsive, self-assembling in-situ drug delivery system for localized periodontal therapy. The invention discloses a flowable precursor composition capable of undergoing a stimuli-induced phase and structural transformation upon exposure to the diseased periodontal microenvironment. The system is specifically designed to respond to a combination of acidic pH conditions and ionic components, including calcium ions present in gingival crevicular fluid. Upon administration into a periodontal pocket, the formulation undergoes rapid in-situ transformation from a liquid state into a micro-structured, semi-solid, mucoadhesive depot. The formed depot exhibits enhanced mechanical retention, resistance to salivary and crevicular fluid washout, and provides sustained and controlled release of therapeutic agents over a prolonged duration of 5-10 days. The formulation comprises a synergistic combination of an antimicrobial agent, bioactive and/or osteogenic agent, and a dual-responsive polymeric matrix capable of pH-sensitive swelling and ion-mediated cross-linking. The invention is characterized by its self-locking behavior, dual-trigger responsiveness, and micro-structured depot formation, resulting in improved therapeutic efficacy, reduced dosing frequency, and enhanced patient compliance. The invention further provides a cost-effective, easily manufacturable system suitable for large-scale clinical and industrial application."
Disclaimer: Curated by HT Syndication.
