MUMBAI, India, Aug. 8 -- Intellectual Property India has published a patent application (202517061709 A) filed by Eli Lilly And Company, Indianapolis, on June 27, for 'methods of dulaglutide purification using hydrophobic interaction chromatography.'
Inventor(s) include Huebner, Amy Lynn; Crowley, Darren Jerome; Catchpole, John Richard; and Clancy, Ceara De Lacy.
The application for the patent was published on Aug. 8, under issue no. 32/2025.
According to the abstract released by the Intellectual Property India: "The present disclosure is directed to methods of purifying a dulaglutide composition. For example, the methods comprise loading the dulaglutide composition in-line with a buffer B solution onto a hydrophobic interaction chromatography (HIC) column in a downflow direction, washing the HIC column with a buffer mixture of a buffer A solution and the buffer B solution in the downflow direction, and eluting dulaglutide from the HIC column. A linear gradient of a percentage of the buffer A and buffer B solutions is used for eluting dulaglutide, which is then followed by an isocratic hold based on a UV absorbance reading of an eluate. The methods further comprise maintaining the isocratic hold until a front side cut is made, and then dropping the buffer B solution for dulaglutide to elute from the HIC column."
The patent application was internationally filed on Dec. 22, 2023, under International application No.PCT/US2023/085746.
Disclaimer: Curated by HT Syndication.
