MUMBAI, India, Jan. 2 -- Intellectual Property India has published a patent application (202541122161 A) filed by Vellore Institute Of Technology, Vellore, Tamil Nadu, on Dec. 4, 2025, for 'method for isolation and metabolomic analysis of plasma derived exosomes.'
Inventor(s) include Dr Sivaraman Jayanthi; Ms. Sanigha P S; Aparna Eledath Kolasseri; and Dr Ramasamy Tamizhselvi.
The application for the patent was published on Jan. 2, under issue no. 01/2026.
According to the abstract released by the Intellectual Property India: "The present disclosure provides isolated plasma-derived exosomes characterized by a metabolomic profile including at least one metabolite selected from alanyl-D-alanine, amphetamine, desmethyldoxepin, acetic acid, 2-propanethiol, and 1,2 dimethylethylamine, where the exosomes have a particle size distribution of 30-200 nm. The exosomes exhibit surface roughness parameters including average roughness (Sa) of 10-18 nm and root mean square roughness (Sq) of 17-32 nm. The exosomes have a particle concentration of 9 108 to 2 109 particles/mL and zeta potential more negative than -30 mV. The disclosure also provides a method for isolating and characterizing plasma-derived exosomes including collecting plasma samples, isolating exosomes using polyethylene glycol precipitation or ultracentrifugation, characterizing using nanoparticle tracking analysis for size distribution and concentration, atomic force microscopy for surface morphology, and gas chromatography-mass spectrometry for metabolite identification."
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