MUMBAI, India, Jan. 9 -- Intellectual Property India has published a patent application (202511112967 A) filed by Maharishi Markandeshwar, Ambala, Haryana, on Nov. 18, 2025, for 'metal-based therapeutic agents: synthesis and bioevaluation of copper, cobalt, and vanadium schiff base chelates.'
Inventor(s) include Dr. Praveen Kumar Gupta; and Sheetal.
The application for the patent was published on Jan. 9, under issue no. 02/2026.
According to the abstract released by the Intellectual Property India: "The present invention relates to the synthesis, characterization, and biological evaluation of Schiff base metal complexes of Copper (Cu), Cobalt (Co), and Vanadium (V) derived from the ligand 2TH-OPDA, prepared by condensation of o-phenylenediamine with 2-thiophene carboxaldehyde. The metal complexes are synthesized by reacting stoichiometric amounts of the ligand with respective metal salts in ethanol under reflux, followed by isolation and drying. The synthesized compounds are characterized using elemental analysis, FTIR, NMR, UV-Vis/DRS, mass spectrometry, and EPR spectroscopy, confirming metal-ligand coordination. In vitro antibacterial studies against Gram-positive (S. aureus, B. subtilis) and Gram-negative (E. coli, P. aeruginosa) strains demonstrate significant antimicrobial activity, while Density Functional Theory (DFT) and molecular docking studies provide insights into geometry, electronic structure, and protein binding interactions. The combined experimental and computational studies establish that these Cu, Co, and V Schiff base complexes are promising candidates for metal-based therapeutic development with potential antimicrobial applications."
Disclaimer: Curated by HT Syndication.
