MUMBAI, India, April 20 -- Intellectual Property India has published a patent application (202647042287 A) filed by Aldexchem Kft., Erd, Hungary, on April 2, for 'ionizable cationic lipids incorporating silicon: synthesis and lnp formulation.'
Inventor(s) include Repasi, Jozsef; and Szilvagyi, Gabor.
The application for the patent was published on April 17, under issue no. 16/2026.
According to the abstract released by the Intellectual Property India: "The present invention belongs to the field of biomedicine and drug delivery as well as pest and vector controls. The invention relates to a novel ionizable cationic lipid family incorporating silicon, which belongs to the trademark LipexSil(R) second generation lipids, wherein the tail is connected to the headgroup with biodegradable silyl acetal linker. Lipids containing silyl acetal linker(s) are state-of-the-art and are effective as ionizable cationic lipids in the formulation of empty or loaded lipid nanoparticles (LNPs). The novel linkers according to the invention are designed by means of proprietary borane catalysts [WO2022129966]. The invention describes the synthesis of the lipids of formula (I), formation and characterization of nanoparticles and biological experiments demonstrating that the lipid nanoparticles prepared with these novel lipids can efficiently deliver their cargo (e.g. RNA, DNA, mRNA, siRNA, dsRNA, pDNA, micro RNA, circular DNA, small biologically active molecules) into the cells."
The patent application was internationally filed on Sept. 05, 2024, under International application No.PCT/IB2024/058653.
Disclaimer: Curated by HT Syndication.
