MUMBAI, India, March 13 -- Intellectual Property India has published a patent application (202641024818 A) filed by Vignan Institute Of Pharmaceutical Technology, Visakhapatnam, Andhra Pradesh, on March 2, for 'ionic liquid-based emulsions for enhanced solubility and bioavailability of poorly water-soluble antifungals.'
Inventor(s) include Y. Srinivasa Rao; P. N. Mallikarjun; S. Satya Lakshmi; U. Bhavani; and K. Srilekhya.
The application for the patent was published on March 13, under issue no. 11/2026.
According to the abstract released by the Intellectual Property India: "The present invention introduces a groundbreaking approach utilizing ionic liquid-based emulsions to significantly improve the solubility and bioavailability of poorly water-soluble antifungal drugs. By incorporating specially designed ionic liquids as stabilizing agents within an oil-in-water emulsion framework, this system overcomes the limitations of traditional formulations, such as low dissolution rates and poor absorption in biological systems. The emulsions are prepared through a controlled ultrasonication process that ensures uniform droplet size and enhanced drug encapsulation. Key components include biocompatible ionic liquids like 1-butyl-3-methylimidazolium tetrafluoroborate, medium-chain triglycerides as the oil phase, and the antifungal agent as the active payload. This formulation not only boosts the drug's aqueous solubility by up to 500-fold but also demonstrates sustained release profiles, leading to improved therapeutic efficacy against fungal infections. Stability tests reveal long-term integrity under various conditions, while in vitro and in vivo studies confirm reduced toxicity and superior antifungal activity compared to conventional solutions. This innovation holds promise for oral, topical, and intravenous applications, addressing critical challenges in antifungal therapy."
Disclaimer: Curated by HT Syndication.
