MUMBAI, India, May 29 -- Intellectual Property India has published a patent application (202641063516 A) filed by Mohan Babu University, Tirupati, Andhra Pradesh, on May 19, for 'formulation of valsartan matrix tablets using tempo-oxidised nano cellulose.'

Inventor(s) include Dr. S. Prasanthi; Ms. Sai Ramya Bodagala; Dr. P. Dhana Lakshmi; and Mr. Kommalapati Naveen Kumar.

The application for the patent was published on May 29, under issue no. 22/2026.

According to the abstract released by the Intellectual Property India: "Valsartan's poor water solubility is a significant barrier to its absorption and therapeutic ef-ficacy. In this study, TEMPO-oxidized nanocellulose (TONC), a novel excipient that en-hances solubility, will be used to develop and evaluate Valsartan matrix tablets. TONC was produced by selective oxidation using the TEMPO-mediated technique from water hya-cinth cellulose source petioles, and its oxidation and nanoscale morphology were verified by FTIR, DSC, and microscopy. Different TONC concentrations were created in matrix tablets using the direct compression technique. The hardness, friability, and weight varia-tion of the tablets were measured both before and after compression in order to assess their physical integrity and compliance with pharmacopeial standards. Drug-excipient compati-bility was examined using FTIR and DSC, and the findings confirmed that there was no discernible interaction between Valsartan and TONC. To assess the impact of TONC con-centration on drug release patterns, dissolution tests were carried out. The findings showed that TONC considerably increased Valsartan's solubility and rate of dissolution in a concentration-dependent manner. Because of the hydrophilic nature of the nanocellulose and better wetting and dispersion, tablets with greater TONC concentrations showed increased drug release. Additionally, every formulation maintained acceptable physical properties, demonstrating the usefulness of TONC as a suitable and functioning excipient.According to the study's findings, TEMPO-oxidized nanocellulose shows promise as a solubility-enhancing agent for medications that are not particularly soluble in water, such as Valsartan, and may find use in sophisticated oral drug delivery systems."

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