MUMBAI, India, July 11 -- Intellectual Property India has published a patent application (202541060957 A) filed by Sandip Sen, Hyderabad, India, on June 26, for 'formulation and optimization of reudragit-l-100 coated polymeric nanoparticles of cefotaxime using tween-80 as surfactant.'
Inventor(s) include Sandip Sen; Mrs. Soumya Stuti Patnaik; Kanukuntla Nikitha; Pallapu Usha Rani; Ankit Kumar Pandit; Kadiri-James Blossom Eshioramhe; P. Ajay Kumar Goud; Neerati Nandithavas; Pasunoori Lokeshwar; Pasula Eshwar; and Nuzahath Sheema.
The application for the patent was published on July 11, under issue no. 28/2025.
According to the abstract released by the Intellectual Property India: "Polymeric nanoparticles are widely used in biomedical applications due to their small size, biocompatibility, and ability to enhance drug properties. Cefotaxime, a broad-spectrum antibiotic, treats infections like meningitis but faces challenges in nanoparticle delivery, such as low encapsulation efficiency and poor stability. Advanced polymeric systems are needed to improve its delivery and prolong therapeutic action. The Eudragit L100 coated nanoparticles was formulated by nano precipitation method using different concentration of surfactant Tween 80. The characterization of the nanoparticles was carried out by entrapment efficiency, particle size and zeta analysis. The morphological study was carried out by ESEM and TEM analysis. Resulting nanoparticles showed good homogeneity, stability, and entrapment efficiency (56-93%). Sizes ranged from 105-149.1 nm with stable zeta potentials (-21.10 to -40.8 mV) and PDI values (0.30-0.61). ESME confirmed smooth, spherical vesicles with intact structure and TEM image confirmed concentric bilayer membrane."
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