MUMBAI, India, Nov. 21 -- Intellectual Property India has published a patent application (202421082581 A) filed by National Forensic Sciences University, Gandhinagar, Gujarat, on Oct. 29, 2024, for 'fluorescent 4-(1,4,5-triphenyl)-1 h-(imidazol-2-yl) phenol derivatives and process for synthesizing the same.'
Inventor(s) include Dr. Mahesh Vasava; Manaswini Karsharma; Abhirami R B; and Riya Khandelwal.
The application for the patent was published on Nov. 21, under issue no. 47/2025.
According to the abstract released by the Intellectual Property India: "Fluorescent 4-(1,4,5-triphenyl)-1 H-(imidazol-2-yl) phenol derivatives and process for synthesizing the same This present invention describes fluorescent imidazole derivatives synthesized using various benzo-halo and alkyl halo compounds through simple alpha-elimination or dehydration reactions using different catalysts. Initially, Aniline, benzil, trimethyl ammonium acetate, and 4-hydroxybenzaldehyde are reacted to produce 4-(1,4,5-triphenyl)-1H-(imidazol-2-yl) phenol, which is then reacted with PCl3, NaCN and then with LiAlH4, to add -CH2. This reaction is followed by oxidation using dichromate, which replaces the alcohol group with aldehyde group, hence forming 4-(1,4,5-triphenyl-1H-imidazol-2-yl)benzaldehyde (1a). This imidazole is then reacted further with a second reagent to produce the final products, (1b-e). The process for synthesis yields five imidazole derivatives (1a-1e) in the range of 80% - 92%. These derivatives give good results in developing fingerprints, DNA analysis, and anti-counterfeiting activities over semi-porous and non-porous surfaces, and show promising probabilities for quenching and explosive detection, antioxidant activity, and other biological activities."
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