MUMBAI, India, Aug. 24 -- Intellectual Property India has published a patent application (202641096268 A) filed by Dr. S. Mohandoss; and Rajalakshmi Engineering College on August 10, 2026, for "fabrication And Characterization Of Electrospun Rutin-Loaded Pva-Collagen-Sodium Alginate Nanofibrous Scaffolds.
Inventor includes Dr. S. Mohandoss.
The application for the patent was published on August 21, 2026, under issue no. 34/2026.
Abstract: The present invention relates to the fabrication and characterization of an electrospun rutin-loaded poly(vinyl alcohol) (PVA)—collagen—sodium alginate (PVA— Collagen—SA) nanofibrous scaffold for biomedical and tissue engineering applications, particularly wound healing. The scaffold is fabricated using an electrospinning process to produce a highly porous, interconnected nanofibrous architecture that closely mimics the native extracellular matrix, thereby providing a favorable microenvironment for cell adhesion, proliferation, and tissue regeneration. Rutin, a naturally occurring flavonoid with potent antioxidant, anti-inflammatory, and antimicrobial properties, is uniformly incorporated within the polymeric matrix to achieve sustained therapeutic release and enhanced biological performance. The fabricated scaffold is characterized using physicochemical techniques including scanning electron microscopy (SEM), Fourier-transform infrared spectroscopy (FTIR), X-ray diffraction (XRD), tensile strength analysis, contact angle measurement, porosity analysis, swelling and degradation studies, and in vitro drug release evaluation to confirm its morphology, composition, mechanical integrity, and functional properties. Biological performance is further assessed through cytocompatibility, antioxidant, and antibacterial studies. The synergistic combination of PVA, collagen, sodium alginate, and rutin results in a biocompatible, mechanically stable, and bioactive nanofibrous scaffold with improved therapeutic efficacy, making it suitable for advanced wound dressing, diabetic wound healing, skin tissue engineering, and other regenerative medicine applications.
Disclaimer: Curated by HT Syndication.
