MUMBAI, India, June 16 -- Intellectual Property India has published a patent application (202611053243 A) filed by Poornima University; and Dr. U. Vinay Kumar, Jaipur, Rajasthan, on April 27, for 'explainable artificial intelligence system for invariant immune biomarker discovery for early and advanced rheumatoid arthritis.'
Inventor(s) include Dr. U. Vinay Kumar.
The application for the patent was published on June 5, under issue no. 23/2026.
According to the abstract released by the Intellectual Property India: "The present invention discloses a computer-implemented system and device for invariant discovery of immune protein biomarkers associated with rheumatoid arthritis using explainable artificial intelligence. The system processes multi-omics single-cell immune profiling data obtained from subjects classified into rheumatoid arthritis, at-risk rheumatoid arthritis, and healthy control categories. The invention employs stratified data partitioning, controlled generation of multiple dataset variants with different class-balance distributions, and application of multiple predictive models to ensure robustness against data imbalance. Explainability processing is used to identify protein markers contributing to classification outcomes, followed by multi-level stability analysis to determine biomarkers that consistently recur across dataset distributions, model configurations, and immune cell types. The final invariant biomarkers are further categorized for disease classification and progression analysis. The invention provides a technically reliable and reproducible solution for early diagnosis and understanding of disease mechanisms, enabling improved clinical decision-making and precision medicine applications."
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