MUMBAI, India, Oct. 24 -- Intellectual Property India has published a patent application (202441030803 A) filed by Kcat Enzymatic Private Limited, Bengaluru, Karnataka, on April 17, 2024, for 'engineered leucine dehydrogenase and applications thereof.'
Inventor(s) include Pravin Kumar R; Gladstone Sigamani G; Roopa L; Abhishek Kumar; Likith M; Anuj Shetty; Naveen Bk; Tharun Bharadwaj L; Poojithrajendran; Jeevan Kallur Prakash; Dhinesh Kumar; Sukesh Narayan Kashyap; Abinaya Rajasekar; and Ashwin Sundar V.
The application for the patent was published on Oct. 24, under issue no. 43/2025.
According to the abstract released by the Intellectual Property India: "Leucine dehydrogenase is a NAD+ dependent oxidoreductase, engineered to perform reductive amination and oxidative deamination. The engineered Leucine dehydrogenase used to prepare amino acids from the keto acid through reductive amination and L-amino acids to a-keto acid through oxidative deamination using an engineered leucine dehydrogenase. The present invention also provides the engineered leucine dehydrogenase polypeptide and nucleotide that can convert a bulky substrate into a respective product. The engineered leucine dehydrogenase in combination with a cofactor regenerating system comprising a formate dehydrogenase and NADPH Oxidase used for performing the reactions. The Leucine dehydrogenase is engineered to form a strong binding affinity and reduces the utilization of formate dehydrogenase. The engineered leucine dehydrogenase polypeptides can be used in several industrial processes, including the synthesis of pharmaceuticals, agrochemicals and fine chemicals by offering a broad substrate specificity and enhanced properties that can significantly benefit a variety of industrial applications."
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