MUMBAI, India, Oct. 11 -- Intellectual Property India has published a patent application (202517089669 A) filed by Wave Life Sciences Ltd., Singapore, on Sept. 19, for 'double stranded oligonucleotide compositions for rna interference and methods relating thereto.'
Inventor(s) include Vargeese, Chandra; Iwamoto, Naoki; Liu, Wei; Luu, Khoa, Ngoc Dang; Kandasamy, Pachamuthu; Marappan, Subramanian; Kumarasamy, Jayakanthan; Shah, Himali, Kavin; Chatterjee, Arindom; Zhang, Fengjiao; Lamattina, Anthony; Liu, Fangjun; Choi, Jeonghoon; Kothari, Nayantara; and Singh, Kuldeep.
The application for the patent was published on Oct. 10, under issue no. 41/2025.
According to the abstract released by the Intellectual Property India: "The present disclosure provides double stranded oligonucleotides, compositions, and methods relating thereto. The present disclosure encompasses the recognition that structural elements of double stranded oligonucleotides, such as base sequence, chemical modifications (e.g., modifications of sugar, base, and/or intemucleotidic linkages) or patterns thereof, and/or stereochemistry (e.g., stereochemistry of backbone chiral centers (chiral intemucleotidic linkages), and/or patterns thereof, can have significant impact on oligonucleotide properties and activities, e.g., RNA interference (RNAi) activity, Ago2 loading, thermal stability, in vivo stability, delivery to tissues and into cells, etc. The present disclosure also provides methods for treatment of diseases, e.g., hepatic diseases, central nervous system (CNS) diseases, etc., using provided double stranded oligonucleotide compositions, for example, in RNA interference."
The patent application was internationally filed on Mar. 01, 2024, under International application No.PCT/US2024/018169.
Disclaimer: Curated by HT Syndication.
