MUMBAI, India, Nov. 21 -- Intellectual Property India has published a patent application (202541084963 A) filed by National Institute Of Pharmaceutical Education And Research, Hyderabad, Telangana, on Sept. 8, for 'dnase i containing nanoformulations to combat cytokine storm via targeting netosis.'
Inventor(s) include Chandraiah Godugu; Priyanka Devi; Shrilekha Chilvery; Biswajit Panda; Rahul Khemchandani; and Gananadhamu Samanthula.
The application for the patent was published on Nov. 21, under issue no. 47/2025.
According to the abstract released by the Intellectual Property India: "The invention provides smart nanoformulation which has an excellent anti-inflammatory and anti-NETs activity for the management of inflammatory diseases with enhanced stability, half-life and provides sustained release of DNase-1 by using the adhesive property of polydopamine. The formulations could also provide patient compliance by reducing number of intravenous administrations required for sepsis by increasing sustained release of dexamethasone and DNase in order to increase efficacy of free Dex and DNase by increasing its further cellular uptake and minimize toxicity."
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