MUMBAI, India, May 1 -- Intellectual Property India has published a patent application (202641022274 A) filed by Mr. Kamalesh Renganathan; Mr. Guru Pranatharthiharan Guru Prabhu; and Dr. Balakrishnaraja R, Sathyamangalam, Tamil Nadu, on Feb. 25, for 'development of a thermoresponsive injectable nanocomposite hydrogel incorporating bioactive glass nanoparticles and egcg for dental pulp regeneration.'
Inventor(s) include Mr. Kamalesh Renganathan; Mr. Guru Pranatharthiharan Guru Prabhu; and Dr. Balakrishnaraja R.
The application for the patent was published on May 1, under issue no. 18/2026.
According to the abstract released by the Intellectual Property India: "Dental pulp injuries resulting from caries, trauma, or infection often lead to irreversible tissue damage, jultimately requiring endodontic interventions that preserve tooth structure but fail to restore its biological !vitality. Current regenerative strategies, including capping agents, synthetic scaffolds, and growth factor delivery, remain limited by poor bioactivity, cytotoxicity, rapid degradation, and lack of functional integration. To address these challenges, this project proposes the development of a novel thermoresponsive injectable hydrogel system based on chitosanl~-glycerophosphate, functionalized with bioactive glass nanoparticles (BG-NPs) and epigallocatechin gallate (EGCG) extracted from green tea. The chitosan matrix !Provides injectability, in situ gelation at body temperature, and antimicrobial properties, while BG-NPs !release calcium, phosphate, and silicate ions to stimulate odontogenic differentiation and mineralization. EGCG contributes antioxidant, anti-inflammatory, and antibacterial functions, thereby protecting regenerating tissue and enhancing stem cell proliferation. Together, these components creaty a multifunctional platform that combines structural support, controlled bioactive release, and biological !Protection within a single scaffold. The study involves the extraction and confirmation of EGCG, sol-gel synthesis of BG-NPs, hydrogel formulation, and comprehensive physicochemical and biological characterizations, including gelation behavior, rheology, drug release, antimicrobial activity, and cytocompatibility using dental pulp stem cells. This injectable nanocomposite hydrogel is expected to provide a clinically translatable, minimally invasive, and cytotoxicity-free alternative capable of promoting !Pulp regeneration, dentin bridge formation, and long-term tooth vitality, thereby overcoming the limitations of existing endodontic therapies. Keywords: Epigal/ocatechin gallate (EGCG), Bioai:tive glass nanopartic/es (BG-NPs), hzjectable thermoresponsive hydrogel, Chitosan/fl-glycerophosphate system, Dental pulp regeneration, Odontogenic differentiation, Controlled release system, Regenerative endodontics."
Disclaimer: Curated by HT Syndication.
