MUMBAI, India, July 11 -- Intellectual Property India has published a patent application (202511059540 A) filed by Chandigarh University, Mohali, Punjab, on June 21, for 'design of a low-shear stirred-tank bioreactor for mammalian cell culture.'
Inventor(s) include Dr. Abhishek Kumar Singh; and Dr. Parul Sharma.
The application for the patent was published on July 11, under issue no. 28/2025.
According to the abstract released by the Intellectual Property India: "The present invention relates to a low-shear stirred-tank bioreactor system specifically designed for the cultivation of mammalian cells, which are highly sensitive to mechanical stress. The bioreactor features a cylindrical vessel compatible with both single-use and stainless-steel configurations and integrates a novel dual impeller system comprising a helical and anchor impeller to generate axial and radial flow patterns. This configuration ensures uniform mixing while minimizing shear damage. A key innovation is the integrated carbon dioxide (CO2) removal system, which employs low-intensity gas overlays, optional membrane-based degassing, and surface agitation to maintain stable pH and osmolality without excessive sparging or foaming. The system is further equipped with embedded sensors and a closed-loop feedback control module interfaced with a PLC or computer, enabling real-time monitoring and dynamic adjustment of culture parameters such as pH, DO, CO2, and cell density. The invention supports scalable and optimized bioproduction for laboratory, pilot, and industrial applications."
Disclaimer: Curated by HT Syndication.
