MUMBAI, India, March 13 -- Intellectual Property India has published a patent application (202611008410 A) filed by University Of Delhi, New Delhi, on Jan. 28, for 'culture-based enumeration of functionally-relevant circulating tumor cells in solid tumors.'
Inventor(s) include Prof. Alok C. Bharti.
The application for the patent was published on March 13, under issue no. 11/2026.
According to the abstract released by the Intellectual Property India: "The present invention discloses a method (100) for detection and functional enrichment of metastasis-competent circulating tumor cells (CTCs) from a peripheral blood sample of a subject suffering from an epithelial or solid tumor malignancy comprising the steps of: obtaining a peripheral blood sample from the subject; isolating a peripheral blood mononuclear cell (PBMC) fraction from the peripheral blood sample; seeding the isolated PBMC fraction into a low-adhesion culture system to establish a three-dimensional culture environment without prior marker-based or physical enrichment of CTCs; culturing the PBMC fraction under non-adherent conditions for a predetermined duration to permit spontaneous formation of three-dimensional spheroidal structures; and detecting and enumerating the spheroidal structures formed in the culture. Further the spheroidal structures represent functionally-relevant circulating tumor cells possessing selfrenewal and proliferative capacity."
Disclaimer: Curated by HT Syndication.
