MUMBAI, India, Jan. 2 -- Intellectual Property India has published a patent application (202541123282 A) filed by Vellore Institute Of Technology, Vellore, Tamil Nadu, on Dec. 6, 2025, for 'carboxymethyl-chitosan scaffolds with sequence dependent crosslinking for tissue engineering.'
Inventor(s) include Dr. Debasish Mishra; Sanjukta Mohan; and Keya Pacholee.
The application for the patent was published on Jan. 2, under issue no. 01/2026.
According to the abstract released by the Intellectual Property India: "The present disclosure provides a carboxymethyl-chitosan scaffold (1) comprising a carboxymethyl-chitosan polymer matrix, glutaraldehyde crosslinks formed through imine linkages between aldehyde groups of glutaraldehyde and amine groups of the carboxymethyl-chitosan, and zinc conjugation through coordination bonds between zinc ions and functional groups of the carboxymethyl-chitosan. The zinc concentration is higher in interior regions compared to exterior surfaces, the scaffold exhibits a swelling ratio below 5 when immersed in aqueous medium, and exhibits anti-biofilm activity against Staphylococcus aureus. The disclosure also provides a method of manufacturing by providing carboxymethyl-chitosan scaffolds formed from an 8% w/v carboxymethyl-chitosan solution, crosslinking with glutaraldehyde to form covalent imine bonds between polymer chains, and subsequently conjugating with zinc ions to form coordination bonds with functional groups, wherein glutaraldehyde crosslinking precedes zinc conjugation."
Disclaimer: Curated by HT Syndication.
