MUMBAI, India, Feb. 6 -- Intellectual Property India has published a patent application (202541123423 A) filed by Saveetha Institute Of Medical And Technical Sciences, Chennai, Tamil Nadu, on Dec. 8, 2025, for 'bioactive herbal mouthwash using rosa and hibiscus rosa sinensis- mediated zno nanoparticles.'
Inventor(s) include Dhanyaa Muthukumar; Rajeshkumar Shanmugam; and Deepak Nallaswamy Veeraiyan.
The application for the patent was published on Feb. 6, under issue no. 06/2026.
According to the abstract released by the Intellectual Property India: "This study aims to evaluate the antimicrobial efficacy of an herbal mouthwash formulated with zinc oxide nanoparticles (ZnO NPs) derived from Rosa and H. sinensis. Zinc oxide nanoparticles (ZnO NPs) have garnered attention for their antimicrobial properties, demonstrating effectiveness against a broad spectrum of pathogenic microorganisms. Moreover, plant extracts such as Rosa and Hibiscus rosa sinensis are wellknown for their medicinal properties, antibacterial and anti-inflammatory effects. This study aims to assess the antimicrobial efficacy of a mouthwash formulation incorporating ZnO NPs derived from Rosa and H. sinensis, providing insight into its potential as a natural alternative for maintaining oral health. The study evaluated a herbal mouthwash formulated with zmc oxide nanoparticles (ZnO NPs) synthesized using extracts of Rosa and H. sinensis, a process confirmed by UV-Vis spectroscopy. Further analysis using a time-kill assay revealed the bactericidal kinetics of the mouthwash over time, showing a reduction in viable bacterial counts. Finally, the Minimum Inhibitory Concentration (MIC) was determined to quantify the lowest effective concentration of the formulation against microl; ial growth. The formulated herbal mouthwash exhibited significant antimicrobial activity against all tested oral pathogens. The largest zones of inhibition were observed against Streptococcus mutans. Time-kill curve analysis illustrates the time-dependent killing of the pathogens at different concentrations of the mouthwash. The largest zones of inhibition were observed against E.faecalis and C. albicans. The herbal mouthwash formulated with zinc oxide nanoparticles synthesized from Rosa and H. sinensis extracts demonstrated potent antimicrobial activity against key oral pathogens."
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