MUMBAI, India, May 29 -- Intellectual Property India has published a patent application (202621042881 A) filed by Prachi Pradip Khobragade; Kaveri Lute; Samiksha Borghare; Aisha Chandankhede; Swati Godghate; Akash Pund; and Rajendra S. Dongre, Gondiya, Maharashtra, on April 3, for 'anti-microbial activity of chitosan-graphene oxide multi-folded with calcium hydroxyapatite-cobalt oxide (chochco) derived metalorganic framework for enhance bio-assay.'
Inventor(s) include Prachi Pradip Khobragade; Kaveri Lute; Samiksha Borghare; Aisha Chandankhede; Swati Godghate; Akash Pund; and Rajendra S. Dongre.
The application for the patent was published on May 29, under issue no. 22/2026.
According to the abstract released by the Intellectual Property India: "The development of multifunctional antimicrobial biomaterials with enhanced structural stability, surface functionality, and biological performance is essential for advanced biomedical and protective applications. In the present study, a novel Graphene Oxide-Chitosan-Hydroxyapatite-Cobalt Oxide (CGOCHCO) composite was synthesized via a casting method and evaluated for its antimicrobial and physicochemical properties. Chitosan, a biodegradable and biocompatible natural polysaccharide, serves as a film-forming polymeric matrix providing inherent antimicrobial characteristics and mechanical flexibility. Hydroxyapatite was incorporated to enhance structural integrity and bioactivity, while graphene oxide was introduced as a nanostructured reinforcing agent to improve mechanical strength, surface area, and interfacial bonding within the composite matrix. Cobalt oxide nanoparticles were integrated to impart potent antimicrobial functionality through reactive oxygen species generation, ion release, and membrane disruption mechanisms. The structural and physicochemical properties of the CGOCHCO composite were characterized using FTIR and BET analysis, confirming successful interaction among functional groups and improved surface characteristics. The composite exhibited enhanced stability and uniform dispersion of inorganic components within the chitosan matrix. Antimicrobial evaluation against Staphylococcus aureus and Pseudomonas aeruginosa demonstrated effective antibacterial performance, confirming the composite's inhibitory potential against both Gram-positive and Gram-negative bacteria. The synergistic integration of biopolymeric, ceramic, carbon-based, and metal oxide components endows the developed composite with improved mechanical integrity and antimicrobial activity. The CGOCHCO composite therefore represents a promising multifunctional material for applications in antimicrobial coatings, wound dressings, implant surface modification, and related biomedical fields, offering a cost-effective and structurally integrated approach toward next-generation antimicrobial biomaterials."
Disclaimer: Curated by HT Syndication.
