Intellectual Property India Publishes Patent Application for 'An Improved Synthetic Process For 1,3-Bis(2-Chloroethyl)Urea(Bcu), A Key Intermediate In Carmustine Synthesis' Filed by National Institute Of Pharmaceutical Education And Research

MUMBAI, India, Sept. 12 -- Intellectual Property India has published a patent application (202411013314 A) filed by National Institute Of Pharmaceutical Education And Research, Mohali, Punjab, on Feb. 23, 2024, for 'an improved synthetic process for 1,3-bis(2-chloroethyl)urea(bcu), a key intermediate in carmustine synthesis.'

Inventor(s) include Manjinder Singh Gill; and Shital Dnyanoba Atpadkar.

The application for the patent was published on Sept. 12, under issue no. 37/2025.

According to the abstract released by the Intellectual Property India: "The present invention provides a process for preparation of 1,3-bis (2-chloroethyl) urea (BCU) having formula (I) which is a key intermediate in the synthesis of Carmustine that is an anticancer drug. The present invention provides a single step, one-pot process for preparing BCU which comprises, reaction of 2-chlorethylamine hydrochloride salt with diphenyl carbonate in the presence of potassium tert. Butoxide in a mixture of solvents ensuring an enhanced yield of 1,3-bis (2-chloroethyl) urea of formula (I). The process provides an easy and cost effective method for obtaining a higher yield of the final product."

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