MUMBAI, India, April 20 -- Intellectual Property India has published a patent application (202411075609 A) filed by Council Of Scientific And Industrial Research, New Delhi, on Oct. 3, 2024, for 'an improved process for synthesis of trifloxystrobin.'
Inventor(s) include Indrajit Das; Abhijit Bankura; Subhadeep Ghosh; Sumit Biswas; Jayanta Saha; and Kumaresh Das.
The application for the patent was published on April 17, under issue no. 16/2026.
According to the abstract released by the Intellectual Property India: "The invention described a new process for synthesizing the fungicide Trifloxystrobin in only five steps using the key intermediate (E)-2-(methoxyimino)-2-(o-tolyl) acetate, resulting in good overall yields. This process is the shortest known route for the preparation of Trifloxystrobin to date, and it eliminates the need for several hazardous chemicals and intermediate steps, such as sodium cyanide, potassium permanganate, Grignard reagent, or diazo reaction. This synthesis involves the preparation of the crucial (E)-2-(methoxyimino)-2-(o-tolyl) acetate intermediate, followed by a bromination and nucleophilic substitution by (Z)-1-(3-(trifluoromethyl)phenyl)ethan-1-one oxime to achieve the final product. The synthesis process is designed to achieve high yield and purity while meeting environmental and process safety standards. Analytical techniques such as NMR and mass spectrometry are utilized to verify the structure and purity of the synthesized Trifloxystrobin, as well as the (E)-2-(methoxyimino)-2-(o-tolyl) acetate intermediate. The process utilizes cost-effective and readily available environmentally friendly materials. This efficient and scalable synthetic route offers a dependable method for producing Trifloxystrobin, contributing to effective fungicidal solutions in agriculture."
Disclaimer: Curated by HT Syndication.
