MUMBAI, India, Feb. 13 -- Intellectual Property India has published a patent application (202421097702 A) filed by Mikusu India Private Limited, Maharashtra, on Dec. 11, 2024, for 'an improved process for manufacturing propaquizafop.'
Inventor(s) include Lakshminarayana, Surapu; Singh, Sunil Kumar; Shetty, Roshan Raghuram; and Shetty, Shriraj Sadashiv.
The application for the patent was published on Feb. 13, under issue no. 07/2026.
According to the abstract released by the Intellectual Property India: "The present invention relates to an improved and industrially applicable process for the preparation of Propaquizafop, a selective aryloxyphenoxypropionate herbicide. The disclosed process involves the catalytic conversion of Quizalofop P alkyl esters with propan 2 one O (2 hydroxyethyl) oxime (IPDO) in an organic solvent under anhydrous conditions, employing selective titanium alkoxide catalysts in catalytic amounts. The process is carried out as a one pot trans-esterification, eliminating intermediate isolation and by simple purification. A key inventive feature is to control dimer and closely related impurities ( 0.5%), while maintaining the optical integrity of the (R) enantiomer without racemization. Eco friendly and recyclable solvents such as toluene, mixed xylene, and DMF, together with mild bases like potassium carbonate, are employed to avoid industrially hazardous reagents and reduce effluent generation. The optimized embodiment consistently delivers high yield (90-95%) and exceptional purity (98-99.9% by HPLC), with reproducibility across batches and simplified work up operations including aqueous quench, layer separation, solvent recovery, and recrystallization. Accordingly, the invention provides a cost effective, scalable, and environmentally sustainable process suitable for both continuous and batch industrial operations, representing a significant advancement in agrochemical synthesis."
Disclaimer: Curated by HT Syndication.
