MUMBAI, India, April 17 -- Intellectual Property India has published a patent application (202621031107 A) filed by Dr. Piyushkumar Sadhu; Dr. Rohit; Anupam Awasthi; Dr. Neeraj Pooni; Vipul Sharma; Mamta Kumari; and Falguni Rathod, Vadodara, Gujarat, on March 15, for 'an amorphous furosemide solid dispersion composition and process thereof.'
Inventor(s) include Dr. Piyushkumar Sadhu; Dr. Rohit; Anupam Awasthi; Dr. Neeraj Pooni; Vipul Sharma; Mamta Kumari; and Falguni Rathod.
The application for the patent was published on April 17, under issue no. 16/2026.
According to the abstract released by the Intellectual Property India: "The invention provides a pharmaceutical capsule formulation overcoming the poor aqueous solubility and limited oral bioavailability of crystalline Furosemide. The composition comprises a physically stable amorphous solid dispersion of Furosemide and Polyvinylpyrrolidone in a 1:2.5 weight ratio, prepared via a solvent-free hot-melt extrusion process at 140 C and a screw speed of 100 RPM. The extrudate is milled and blended with 0.5% to 5% w/w curcumin as a bioavailability enhancer. Polyvinylpyrrolidone stabilizes the amorphous state and enhances dissolution, while curcumin improves intestinal absorption and prevents metabolic loss. The combined use of Quercetin and curcumin provides a synergistic enhancement in the systemic plasma concentration of Furosemide compared to conventional dosage forms. The final blend is filled into hard gelatin or HPMC capsules for effective oral delivery."
Disclaimer: Curated by HT Syndication.
