MUMBAI, India, May 29 -- Intellectual Property India has published a patent application (202611051128 A) filed by Mr. Jatin Kishore Sharma; and Dr. Sushil Kumar, Moradabad, Uttar Pradesh, on April 22, for 'alkylation of hydroxy chalcone using carbonate bases.'
Inventor(s) include Mr. Jatin Kishore Sharma; and Dr. Sushil Kumar.
The application for the patent was published on May 29, under issue no. 22/2026.
According to the abstract released by the Intellectual Property India: "The present invention relates to an improved process for alkylation of hydroxy chalcone at the phenolic hydroxyl group using carbonate bases via nucleophilic substitution. The method employs 1-bromo-3-chloropropane as alkylating agent and acetonitrile as solvent. Carbonate bases including potassium, sodium, and cesium carbonate facilitate deprotonation to form a phenoxide ion, which reacts to yield alkoxy chalcone derivatives. Cesium carbonate shows highest yield (91%) due to weak ion pairing, while potassium carbonate provides balanced yield (78%), selectivity, and cost-effectiveness. Sodium carbonate shows lower yield (52%). The process offers optimized conditions for synthesizing pharmaceutical intermediates."
Disclaimer: Curated by HT Syndication.
