MUMBAI, India, May 1 -- Intellectual Property India has published a patent application (202611023035 A) filed by Dr Jyoti Maithani Kalra; Dr Kapil Kalra; Dr Amit Kumar Joshi; Dr Shiba Shiphalika Morris; Md Sadique Hussain; Dr Ajay Singh Bisht; and Dr Sanjay Singh, Dehradun, Uttarakhand, on Feb. 26, for 'ai guided surface functionalized mesoporous carrier based amorphous solid dispersion system and method for enhancing dissolution rate and physical stability of rifabutin.'
Inventor(s) include Dr Jyoti Maithani Kalra; Dr Kapil Kalra; Dr Amit Kumar Joshi; Dr Shiba Shiphalika Morris; Md Sadique Hussain; Dr Ajay Singh Bisht; and Dr Sanjay Singh.
The application for the patent was published on May 1, under issue no. 18/2026.
According to the abstract released by the Intellectual Property India: "The present invention relates to pharmaceutical formulation science and advanced drug delivery systems, and more particularly to an artificial intelligence (AI) assisted excipient optimization system for developing a surface functionalized mesoporous carrier based amorphous solid dispersion (ASD) of poorly water soluble drugs, specifically Rifabutin. The invention integrates a predictive AI engine configured to evaluate physicochemical parameters including hydrogen bonding potential, Hansen solubility compatibility, crystallization risk index, and glass transition temperature enhancement to autonomously select optimal excipient combinations prior to formulation. Rifabutin is molecularly dispersed within a surface functionalized mesoporous carrier having a pore size of 2-10 nm and surface area of 500-1200 m/g, enabling nano confinement and chemical anchoring to suppress recrystallization. The drug loaded carrier is incorporated into a polymeric stabilization matrix selected from pharmaceutically acceptable polymers to restrict molecular mobility and maintain residual crystallinity below 2%."
Disclaimer: Curated by HT Syndication.
