MUMBAI, India, Jan. 9 -- Intellectual Property India has published a patent application (202531129712 A) filed by National Institute Of Technology, Rourkela, Orissa, on Dec. 20, 2025, for 'a scalable bioprocess platform for enhanced production of bacosides using bacopa monnieri cell cultures.'
Inventor(s) include Dr. Nivedita Patra; and Jayashree Nanda.
The application for the patent was published on Jan. 9, under issue no. 02/2026.
According to the abstract released by the Intellectual Property India: "The present invention provides an integrated bioprocess platform for the large-scale production of bacosides from Bacopa monnieri. The process involves Agrobacterium tumefaciens-mediated genetic transformation of leaf-derived callus to generate high-yielding transgenic cell lines, such as the P7 line, which are selected via molecular and chromatographic confirmation. These cell lines are subsequently cultivated in a stirred-tank bioreactor under controlled conditions-including 130 rpm agitation, 0.05 vvm aeration, and darkness-to maintain a stable callus suspension. The biosynthetic yield is further maximized through the timed addition of a statistically optimized elicitor cocktail of salicylic acid, methyl jasmonate, and copper sulphate. This method achieves a 5-fold increase in bacoside A production compared to un-optimized cultures, providing a scalable and sustainable biomanufacturing solution for pharmaceutical grade bacosides."
Disclaimer: Curated by HT Syndication.
