MUMBAI, India, Feb. 27 -- Intellectual Property India has published a patent application (202641017311 A) filed by Dr. K. Selvakumar; Mr. Sanjeevigari Vishnu Vardhan; Dr. Joysa Ruby J; Dr. Hemalatha K; and Dr. Venkatesh DP, Bengaluru, Karnataka, on Feb. 17, for 'a quality-by-design optimized mucoadhesive oral film composition and manufacturing method for enhanced bioavailability of a prostacyclin receptor agonist.'
Inventor(s) include Dr. K. Selvakumar; Mr. Sanjeevigari Vishnu Vardhan; Dr. Joysa Ruby J; Dr. Hemalatha K; and Dr. Venkatesh DP.
The application for the patent was published on Feb. 27, under issue no. 09/2026.
According to the abstract released by the Intellectual Property India: "The present invention relates to a mucoadhesive oral thin-film pharmaceutical composition designed for systemic delivery of a prostacyclin receptor agonist with improved bioavailability and patient compliance. The oral film is formulated using a hydrophilic film-forming polymer and at least one plasticizer to provide rapid disintegration in the oral cavity, enabling absorption through the oral mucosa and reducing the effect of hepatic first-pass metabolism. The invention integrates a Quality-by-Design based development approach supported by structured risk assessment methodologies to identify and control critical quality attributes, critical material attributes, and critical process parameters. The optimized oral film exhibits uniform low-dose drug distribution, acceptable mechanical properties, rapid disintegration, and reproducible performance, thereby providing a robust, scalable, and patient-friendly alternative to conventional oral solid dosage forms for the management of pulmonary arterial hypertension and related conditions."
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