MUMBAI, India, Sept. 12 -- Intellectual Property India has published a patent application (202411012579 A) filed by Council Of Scientific And Industrial Research, New Delhi, on Feb. 21, 2024, for 'a process for the production of actinomycin d.'
Inventor(s) include Asha Chaubey; Neha Sharma; Ravi Singh Manhas; Yedukondalu Nalli; Mahendra Kumar Verma; Amit Kumar; and Dumbala Srinivasa Reddy.
The application for the patent was published on Sept. 12, under issue no. 37/2025.
According to the abstract released by the Intellectual Property India: "The present invention describes a fermentation process with specifically designed medium for improved production of pharmaceutically important drug (actinomycin D) using actinobacterial strain Streptomyces marokkonensis MTCC-25511, isolated from cold deserts of NW Himalayas (Barchey) India. The process involves 12 days fermentation under specific fermentation conditions i.e. temperature 28OC 2OC, pH7.0 2.0 with 10% inoculum size followed by downstream processing involving purification of actinomycin D by conventional solvent as well as single step purification method. The direct single step purification involved binding of the metabolites of fermented broth with ion exchange resin and elution of pure compound Actinomycin D using methanol/water/acetone. The present invention provided high productivity i.e. ~15mg/L/h of actinomycin D with 95% purity."
Disclaimer: Curated by HT Syndication.
