MUMBAI, India, Feb. 13 -- Intellectual Property India has published a patent application (202641008789 A) filed by Vellore Institute Of Technology, Vellore, Tamil Nadu, on Jan. 28, for 'a process for isolation of a thermostable microbial protease inhibitor.'
Inventor(s) include Aparana Kumari; Dr. K. V. Bhaskara Rao; Dr. Deepti Parashar; Dr. Kalichamy Alagarasu; and Poonam Patil.
The application for the patent was published on Feb. 13, under issue no. 07/2026.
According to the abstract released by the Intellectual Property India: "The invention discloses an optimized and scalable method for isolating a bioactive protease inhibitor from a thermophilic microbial source obtained from a geothermal environment, as schematically illustrated in 00. The process comprises selective cultivation of the microbial isolate, separation of a cell-free supernatant, solvent-based extraction, and purification to obtain a stable and biologically active inhibitor. Chemical characterization of the isolated inhibitor is carried out using gas chromatography-mass spectrometry and Fourier-transform infrared spectroscopy, as illustrated in Figures 400 and 500. The isolated protease inhibitor exhibits significant serine protease inhibitory activity, as demonstrated by protease inhibition assays shown in Figure 300. The invention further discloses antiviral application of the inhibitor against dengue virus, as confirmed by in vitro cytotoxicity and antiviral efficacy studies illustrated in Figures 600 and 700. In vivo safety evaluation, as shown in Figures 800 and 900, demonstrates a favorable toxicity profile."
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