MUMBAI, India, July 11 -- Intellectual Property India has published a patent application (202541044579 A) filed by Sumathi Arumugam; Surlyaprakash Timmakondu Narasimman Kuppusami; Balan Paramasivam; Eugine Leo Prakash Soosai Raj; Thirumaran Jegadeeswaran; Ashok Kumar Janakiraman; Lathamant Lakshmanan; Dhanasekar Jayakumar; and Sivasankari Madeshwaran, Erode, Tamil Nadu, on May 8, for 'a novel pharmaceutical composition of polyherbal ointment for anti-inflammatory therapy.'
Inventor(s) include Sumathi Arumugam; Surlyaprakash Timmakondu Narasimman Kuppusami; Balan Paramasivam; Eugine Leo Prakash Soosai Raj; Thirumaran Jegadeeswaran; Ashok Kumar Janakiraman; Lathamant Lakshmanan; Dhanasekar Jayakumar; and Sivasankari Madeshwaran.
The application for the patent was published on July 11, under issue no. 28/2025.
According to the abstract released by the Intellectual Property India: "In the present investigation, a novel polyherbal ointment is formulated and screened for its anti-inflammatory activity. Physicochemical parameters viz. Appearance (colour, texture, homogeneity), Odor, rH, Viscosity, Spreadability, Consistency, Melting point, Drug content uniformity, Specific gravity, Loss on drying (moisture content), In vitro drug release, Extrudability, Wettability and Stability were evaluated for the formulated novel polyherbal ointment. This novel poly herbal ointment comprises I 0 % of Allium sativum peel extract, I 0 % of Myristica fragrans seed extract, I 0 % of Vitex negundo leaf extract, 10% of Piper nigrum fruit extract, 5% of Eucalyptus globulus oil, and 5% of Edible Cinnamomum camphnra. It showed highest drug release of 89.0 I 0.03 % after 6 h of in viiro release study as compared to other formulations. Using in vitro protein denaturation egg albumin method, the inhibition of protein denaturation of the prepared novel polyherbal ointment at various concentrations viz. 50 J.lg/mL, I 00 J.lg/mL, 250 J.lg/mL, 500 J.lg/mL was found to be 81 %, 69 %, 61 %, and 57 % respectively (ICso value: 212.31 11g/mL). Inhibition of haemolysis of the prepared novel polyherbal ointment was studied at various concentrations viz. 25 11g/mL, 50 J.lg/mL, 75 J.lg/mL, and 100 J.lg/mL by in vitro HRBC (Human Red Blood Cell) membrane stabilization method was found to be 93 %, 88 %, 85 %, and 81 % respectively (!Cso value: 15.06 11g/mL). The composition of optimized polyherbal formulation significantly inhibited the inflammation to the extent of 75.63% when compared to the control and standard topical base group after 3 h from carrageenan injection. The statistical data analysis was done by one-way analysis of variance followed by Dunnett's test using GraphPad version 7 {p<0.05). Thus, the present study concluded the more significant anti-inflammatory activity of the prepared novel polyherbal ointment."
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