MUMBAI, India, May 1 -- Intellectual Property India has published a patent application (202631049070 A) filed by Dr. Mossaraf Hossain, Dinhata, West Bengal, on April 17, for 'a novel environmentally sustainable and non-photocatalytic method for the production of imidazole n-oxides using visible light.'
Inventor(s) include Dr. Mossaraf Hossain; Ms. Kaberi Sikdar; Mr. Manirul Mandal; Mr. Koustav Singha; and Mr. Imran Habib.
The application for the patent was published on May 1, under issue no. 18/2026.
According to the abstract released by the Intellectual Property India: "A novel environmentally sustainable and non-photocatalytic method for the production of imidazole N-oxides using visible light ABSTRACT A novel environmentally sustainable and non-photocatalytic visible-light-mediated synthesis of Imidazole N-oxide derivatives has been established in aqueous ethanol via formation of an electron donor-acceptor (EDA) complex under mild, sustainable conditions. The present invention discloses a method for synthesis of Imidazole N-oxide derivatives from a mixture of monoxime (1equivalent), aromatic amines (1 equivalent) or ammonium acetate (2 equivalents) or hydroxylamine hydrochloride (2 equivalents), and aldehyde (1 equivalent) in aqueous ethanolic medium (H2O/EtOH, 2:1, v/v) stirred under irradiation from two 9 Watt Blue Light Emitted Diodes at room temperature for (2 -24) hours. The stoichiometry of the reactants in the EDA complex was determined by the Job's plot, which confirmed 1:1 complexation between 1+ 4f and 2a. The binding constant (Ka) was assessed by the modified Benesi-Hildebrand equation and found to be 1.1975 106 M-1. The present invention is a mechanistically supported, scalable, and sustainable visible-light-driven method for the synthesis of imidazole N-oxide derivatives."
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