MUMBAI, India, May 29 -- Intellectual Property India has published a patent application (202641043647 A) filed by S. Ignacimuthu, S. J., Tirunelveli, Tamil Nadu, on April 6, for 'a novel derivative of dehydrozingerone for treating calcium oxalate kidney stones and its method of preparation.'
Inventor(s) include S. Ignacimuthu, S. J.; P. Pandikumar; S. Rithick; K. Razak Deen; M. Muthumari; K. Balakrishna; and K. Buvanesvara Gurunathan.
The application for the patent was published on May 29, under issue no. 22/2026.
According to the abstract released by the Intellectual Property India: "A novel molecule namely, dehydrozingerone. druun:rHlt~ with.th~.followine; stmc.tnm was identified for treating calcium oxalate (CaOx) kidney stones. Dehydrozingerone was synthesized by aldol condensation of vanillin with acetone in an alkaline medium. By Steglich esterification, dehydrozingerone was esterified with cinnamate. At 50 1-1M concentration, dehydrozingerone cinnamate lowered CaOx nucleation by 75.23%; at this concentration the parent molecules failed to show any inhibition. Incubating CaOx stones in dehydrozingerone cinnamate solution at 100 1-1M concentration for 24 h, significantly lowered the stone mass by 22.76%. In CaOx-intoxicated Vero cells, dehydrozingerone cinnamate treatment significantly restored the cell viability and lowered CaOx adhesion on the cells. The effect of dehydrozingerone cinnamate was superior to that of dehydrozingerone and cinnamic acid."
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